Accession Number:

AD0672943

Title:

EFFECT OF LYOPHILIZED MEDIA COMPOSITION ON BACTERIAL VIABILITY IN DRY LIVE ANTI-PLAGUE VACCINE

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Pechnikova, I. V.

Report Date:

1965-09-17

Pagination or Media Count:

8.0

Abstract:

Lyophilization media containing 0.4 ammonium molybdate, 1 thiourea or 1.5 sodium glutamate, 0.5 thiourea, and 0.05 peptone contributed to longer preservation of live bacteria in a dry anti-plague vaccine with an unfavorable high storage temperature. With a storage temperature of 37C the vaccine prepared on these lyophilization media retained the minimum percentage of live bacteria for 16 days at 28C -- for 50 days, and at room temperature, for 8-9 months.

Descriptors:

• *SODIUM COMPOUNDS
• USSR
• TEMPERATURE
• DEXTRAN
• GLUTAMIC ACID
• FREEZE DRYING
• VIABILITY
• ADDITIVES
• AMMONIUM COMPOUNDS
• TRANSLATIONS
• THIOUREA
• PEPTONES
• ASCORBIC ACID
• STORAGE
• PRESERVATION
• CARBOHYDRATES
• VACCINES
• GELATINS
• CULTURE MEDIA
• MOLYBDATES

Subject Categories:

• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE