Accession Number:

AD0672895

Title:

EFFECTIVENESS OF DRUGS IN ANIMALS EXPOSED TO MIXED GAMMA-NEUTRON RADIATIONS. IV. DRUG TOXICITY

Descriptive Note:

Technical Report

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD BETHESDA

Personal Author(s):

• Davis,L. W.
• Strike,T. A.

Report Date:

1968-05-01

Pagination or Media Count:

19.0

Abstract:

The acute toxicity death within 24 hours of 10 drugs representing four drug classes anticonvulsants, hypnotics, hypoglycemics, and psychopharmacologics was studied in irradiated male CF1 mice 2 hours, 1 day, or 6 days after 500-, 1000-, and 10,000-rad whole body doses of mixed gamma-neutron radiations. The LD50 value for each drug in irradiated mice was calculated and compared to the LD50 value obtained in unirradiated controls. Although the LD50 values for most drugs studied were altered significantly in some of the dose groups of irradiated mice, no definite pattern of change of drug toxicity with respect to either radiation dose or postirradiation time was identified.

Descriptors:

• RADIATION EFFECTS
• TOXICITY
• ANTICONVULSANTS
• HYPNOTICS AND SEDATIVES
• PSYCHOTROPIC drugs
• WHOLE BODY IRRADIATION
• LETHAL DOSAGE
• GAMMA RAYS
• NEUTRONS
• RADIOBIOLOGY

Subject Categories:

• Radiobiology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE