Accession Number:

AD0672727

Title:

AEROSOL IMMUNIZATION WITH DRY POWDER VACCINES AND TOXOIDS. COMMUNICATION, 9. FURTHER STUDY OF REACTIVENESS AND IMMUNOLOGICAL EFFECTIVENESS OF THE METHOD OF AEROSOL IMMUNIZATION WITH THE BRUCELLOSIS DUST VACCINE (AEROZOLNAYA IMMUNIZATSIYA SUKHIMI PYLEVYMI VAKTSINAMI I ANATOKSINAMI. SOOBSHCHENIE 9. DALNEISHEE IZUCHENIE REAKTOGENNOSTI I IMMUNOLOGICHESKOI EFFEKTIVNOSTI METODA AEROZOLNOI IMMUNIZATSII PYLEVOI BRUTSELLEZNOI VAKTSINOI)

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Aleksandrov, N. I.
• Gefen, N. E.
• Gapachko, K. G.
• Garin, N. S.
• Maslov, N. S.

Report Date:

1968-07-01

Pagination or Media Count:

21.0

Abstract:

All virtually healthy people of both sexes, between the ages of 18 and 60, who have no medical contraindications to inoculations and are not sensitized to the brucellosis infection, can be admitted to aerosol immunization with the brucellosis dust vaccine. The optimal dose of the brucellosis dust vaccine, inhaled by the vaccinated person, is a dose equaling 250-820 1000 million live Brucella of the vaccinal strain 19BA. In mass aerosol immunization of people with the brucellosis dust vaccine, the reactiveness of vaccinations is determined by the number of persons among them who are sensitized to brucellosis. In the absence of positive sero-allergic reactions in persons, who previously underwent subcutaneous cutaneous inoculations with the live brucellosis vaccine, their aerosol revaccination with the brucellosis dust vaccine did not produce any increased reaction. Aerosol immunization produced a rapid and long lasting immunologic reorganization of the organism of the vaccinated, which was registered, during the course of a year.

Descriptors:

• *VACCINES
• *BRUCELLA
• *BACTERIAL AEROSOLS
• USSR
• DUST
• DOSAGE
• TRANSLATIONS
• RESPIRATION
• IMMUNITY
• ANTIGEN ANTIBODY REACTIONS
• ALLERGIC DISEASES

Subject Categories:

• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE