Accession Number:

AD0672104

Title:

THE MECHANISM OF ACTION OF CHLORAMPHENICOL. III. THE EFFECT OF CHLORAMPHENICOL ON THE ASSIMILATION OF PYRUVIC ACID BY VARIOUS BACTERIAL SPECIES,

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Korotyaev,A. I.

Report Date:

1968-07-01

Pagination or Media Count:

9.0

Abstract:

Chloramphenicol sharply inhibits the assimilation of pyruvic acid by the cells of the colon bacillus, Flexners bacillus, and Staphylococcus aureus. Unimpaired cells of lactic-acid and hemolytic streptococci do not assimilate pyruvic acid. It is presumed that these bacteria lack the necessary exoenzymes, or, possibly, that their carbohydrate metabolism takes place without the phase of forming pyruvic acid. It is possible that the disruption of the bacterial carbohydrate metabolism is accompanied by a disruption of the metabolisms energy processes. Author

Descriptors:

• (*ENTEROBACTERIACEAE
• ANTIMETABOLITES)
• (*CHLORAMPHENICOL
• ANTIMETABOLITES)
• PROTEINS
• BIOSYNTHESIS
• INHIBITION
• METABOLISM
• CARBOHYDRATES
• PYRUVIC ACID
• SHIGELLA FLEXNERI
• STAPHYLOCOCCUS AUREUS
• USSR

Subject Categories:

• Microbiology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE