Accession Number:

AD0672077

Title:

OPERATION OF A PRIMARY ANTIMALARIAL SCREEN.

Descriptive Note:

Annual progress rept. 1 Jul 67-30 Jun 68,

Corporate Author:

IIT RESEARCH INST CHICAGO ILL

Personal Author(s):

• King,Maurice E.
• Shefner,Alan M.

Report Date:

1968-06-01

Pagination or Media Count:

19.0

Abstract:

The objectives of this program are to test new compounds in a primary screen for effectiveness against blood-induced Plasmodium berghei and to develop methods for use in screening against sporozoite-induced infections in mice and chicks. A total of 2554 compounds were screened in the blood-induced mouse test system. A colony of Aedes aegypti mosquitoes was established for infecting chicks with Plasmodium gallinaceum and a protocol was developed for a test system for the sporozoite-induced infection. Considerable effort has been spent in obtaining reproducible cyclical passage of P. berghei yoelii sporozoites from Anopheles stephensi mosquitoes to mice. Author

Descriptors:

• *ANTIMALARIALS
• AEDES
• ANOPHELES
• PLASMODIUM
• TOXICITY
• PARASITIC DISEASES
• DRUGS
• INFECTIOUS DISEASES
• CHEMOTHERAPEUTIC AGENTS

Subject Categories:

• Microbiology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE