Accession Number:

AD0671806

Title:

ONTOGENY OF THE MOUSE IMMUNE SYSTEM: IMMUNOGLOBULIN PRODUCING CELLS,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Report Date:

1968-05-14

Pagination or Media Count:

16.0

Abstract:

When mouse fetal tissues of various ages were transferred to allogeneic or congenic hosts which differed from the immunoglobulin locus Ig 1, it was found that cells which have the potential to differentiate into immunoglobulin producing cells appear in the yolk sac, liver and caudal half of the embryo by the 9th day of gestation. Late in pregnancy these cells are found in the thymus, gut, lung, spleen, femur and peripheral blood. Certain of the data suggest that immunoglobulin producing cell lines and those which mediate cell-bound immune response arise early ingestation as separate cell populations. Further, it was shown that immunoglobulin synthesis per se is independent of the thymus. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE