STUDIES ON THE ANTIVIRAL ACTIVITY OF GUANYLHYDRAZONES ESPECIALLY AGAINST ARBO- AND MYXO-VIRUSES
Technical Report,01 Apr 1967,01 Apr 1968
KITASATO INST TOKYO (JAPAN) TOKYO
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Alkoxy benzalacetone amidinohydrazones and N, N anhydrobis 2-hydroxyetyl amidinohydrazones were newly synthesized and antiviral effectiveness of these derivatives against influenza virus was investigated. Out of 39 compounds, 31 derivatives 79.5 of total compounds tested were found to possess the virucidal activity, and 13 compounds 33.3 were of antiviral effectiveness against the virus with the chemotherapeutic ratio of 2 or greater. Five derivatives had highly virucidal effectiveness to the virus with the minimal concentration as low as 1.6 microgramsml or 0.8 microgramsml in final. Three out of five derivatives have been found to be active with one-sixtyfourth less concentration of their cytotoxic doses. By the inhibition test, seven compounds had antiviral activity to the virus with the final concentration of 12.5 microgramsml or less.