Accession Number:

AD0671380

Title:

ANTHRAX TOXIN: PRIMARY SITE OF ACTION

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Report Date:

1968-02-01

Pagination or Media Count:

11.0

Abstract:

Administration of anthrax toxin via the cerebrospinal fluid demonstrates positively that the toxin alters the bodys physiology, primarily via the central nervous system, and kills by terminal anoxia mediated by the central nervous system. The use of a positive-pressure respirator and isoproterenol prevented death in animals that had received lethal doses of toxin. This demonstration of therapy for a lethal bacterial toxin opens new avenues of investigation.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE