Accession Number:

AD0671379

Title:

NEUROLOGICAL AND PHYSIOLOGICAL RESPONSES OF THE PRIMATE TO ANTHRAX INFECTION

Descriptive Note:

Journal article

Corporate Author:

FORT DETRICK FREDERICK MD

Report Date:

1968-02-01

Pagination or Media Count:

7.0

Abstract:

A depression of the cortical electrical activity, observed on electroencephalograms, and subsequent respiratory failure occurred in rhesus monkeys dying of anthrax. The cardiac activity and respiratory rate did not change during the disease until, as evidenced by respiratory patterns, acute respiratory distress occurred. At this time typical anoxic responses were observed. White blood cell counts and hematocrit readings increased late in the course of disease and several hours after a septicemia had been observed. A terminal toxemia was demonstrable. The terminal responses were essentially identical to those that we have reported for rhesus monkeys and chimpanzees challenged with lethal amounts of sterile anthrax toxin. Anthrax is now visualized as a clinically new disease with many similarities to plague, diphtheria, tetanus, and other lethal toxigenic diseases.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE