THE EFFECTS OF HIPPOCAMPAL AND PYRIFORM ABLATIONS ON THE FORMATION OF MEMORY IN THE CAT (WITH APPENDIX ON ABLATION TECHNIQUES).
CORNELL UNIV ITHACA N Y COGNITIVE SYSTEMS RESEARCH PROGRAM
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A review of the literature indicates that hippocampal ablation interferes with the post-operative acquisition of unfamiliar problems, but does not interfere with the retention of pre-operatively learned problems. This evidence from the literature is consistent with the hypothesis that the hippocampal region is essential for the formation of memory, but not for its storage or recall. This hypothesis was tested experimentally by use of another experimental design. The learning abilities of ablated and normal cats were compared on problems with familiar and unfamiliar cues. The operated animals were inferior to the normal animals on the problems with unfamiliar cues p 0.041 but not on the problems with familiar cues p 0.197. The literature reviewed and these experimental results both strongly suggest that the hippocampi andor pyriform cortices contain basic parts of the memory forming mechanism, but do not contain essential parts of the memory storage or recall mechanisms. Author
- Anatomy and Physiology