SCHISTOSOMIASIS DRUG SCREENING.
Annual rept. no. 2, Jun 67-May 68,
MINAS GERAIS UNIV BELO HORIZONTE (BRAZIL) INSTITUTO DE BIOLOGIA
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After a preliminary toxicity test, 1,005 WR compounds were tested in mice experimentally infected with Schistosoma mansoni. The oogram method was used for assessing antischistosomal activity. Fifteen WR compounds displayed antischistosomal activity in mice Triphenyl bismuth Quinine, derivatives and isomers 10 compounds Thiosinamine Diaminodiphenyl sulfone 4,4 diformamido diphenylsulfone and one Quinoline methanol. Some of the active compounds were further studied in mice, hamsters and Cebus monkeys experimentally infected with S. mansoni. Besides oogram changes, the hepatic shift of worms was also used for the evaluation of antischistosomal activity. The results are discussed. Author