CELLULAR AND TISULAR ADAPTATION TO HYPOXIA.
Annual rept. no. 2, Apr 67-Mar 68,
UNIVERSIDAD PERUANA CAYETANO HEREDIA LIMA FACULTAD DE MEDICINA
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The following adaptive mechanisms to chronic hypoxia are under investigation 1 Larger PO ratio in vivo 2 Increased anaerobic energy production 3 Changes in citric acid cycle intermediate concentrations. The concentrations of L-Lactate and L-alpha-glycerophosphate in red muscle, white muscle, liver and heart from high altitude guinea pigs, under aerobic and ischemic conditions were determined. Considering the results obtained, enough evidence is presented to discard a previous hypothesis, which stated that L-alpha-glycerophosphate has an important role as final product of anaerobic glycolysis. The results of these investigations show a reduced accumulation of these substances in the ischemic liver of animals from high altitude as compared to those from sea level. This suggests among other possibilities that liver tissue of animals adapted to chronic hypoxia metabolize L-Lactate more efficiently in ischemic conditions. The results in other tissues are also discussed. Using gas-liquid chromatography, red muscle, liver, heart and kidney tissue under conditions of ischemia at sea level and high altitude were analyzed for the Krebs cycle intermediates. Succinic, malic, and citric acids are easily measurable. Obvious differences in succinic acid concentration were found between the two groups, and 2 unknown substances were found only in kidney and heart tissue from high altitude animals. Author
- Anatomy and Physiology