Accession Number:

AD0670932

Title:

BLOOD PLASMA LEVELS AND ELIMINATION OF SALTS OF 2-PAM IN MAN AFTER ORAL ADMINISTRATION,

Descriptive Note:

Corporate Author:

EDGEWOOD ARSENAL MD

Personal Author(s):

• Kondritzer,Albert A.
• Zvirblis,Peter
• Goodman,A.
• Paplanus,S. H.

Report Date:

1968-06-01

Pagination or Media Count:

25.0

Abstract:

Adult male volunteers were given, orally, aqueous solutions of each of the chloride, iodide, dihydrogen phosphate, methane sulfonate, and lactate salts of 2-PAM in varying amounts. A measurable amount of oxime was found in blood plasma within about 15 minutes the concentration rose rapidly, reached a peak at 2 to 3 hours, and then declined at a rate that approximated a first-order process. The rates of absorption into and elimination from plasma of 2-PAMCl and P2S were practically identical. The equation, log Y 0.79 0.54 log X, gives an approximate relationship between peak plasma levels of oxime Y and oral doses X of the various salts. Accordingly, a 10-fold increase in dosage of the 2-PAM salts increased the peak plasma level of oxime 3.5 fold. The biological half-life in man of the 2-PAM salts given orally, calculated from blood plasma values and urinary excretion rates, was 1.7 hours, with a coefficient of variation of 24. The average total amount of 2-PAM recovered in the urine was 27 the standard deviation of individual recoveries was 9. Considerably less EA 1814 is excreted via the urine an average of 3 was recovered during 24 hours among three subjects. Clinical changes observed were 1 iodism symptoms in subjects given 2-PAM and 2 a 20 decrease in both RBC and plasma cholinesterase in subjects given 1 gm70 kg of EA 1814. All other clinical tests were negative. Author

Descriptors:

• *BLOOD CHEMISTRY
• EXCRETION
• OXIMES
• CHOLINESTERASE INHIBITORS
• DETOXIFICATION
• URINE
• BIOLOGICAL ABSORPTION
• DOSAGE

Subject Categories:

• Biochemistry
• Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE