DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click HERE
to register or log in.
BLOOD PLASMA LEVELS AND ELIMINATION OF SALTS OF 2-PAM IN MAN AFTER ORAL ADMINISTRATION,
EDGEWOOD ARSENAL MD
Pagination or Media Count:
Adult male volunteers were given, orally, aqueous solutions of each of the chloride, iodide, dihydrogen phosphate, methane sulfonate, and lactate salts of 2-PAM in varying amounts. A measurable amount of oxime was found in blood plasma within about 15 minutes the concentration rose rapidly, reached a peak at 2 to 3 hours, and then declined at a rate that approximated a first-order process. The rates of absorption into and elimination from plasma of 2-PAMCl and P2S were practically identical. The equation, log Y 0.79 0.54 log X, gives an approximate relationship between peak plasma levels of oxime Y and oral doses X of the various salts. Accordingly, a 10-fold increase in dosage of the 2-PAM salts increased the peak plasma level of oxime 3.5 fold. The biological half-life in man of the 2-PAM salts given orally, calculated from blood plasma values and urinary excretion rates, was 1.7 hours, with a coefficient of variation of 24. The average total amount of 2-PAM recovered in the urine was 27 the standard deviation of individual recoveries was 9. Considerably less EA 1814 is excreted via the urine an average of 3 was recovered during 24 hours among three subjects. Clinical changes observed were 1 iodism symptoms in subjects given 2-PAM and 2 a 20 decrease in both RBC and plasma cholinesterase in subjects given 1 gm70 kg of EA 1814. All other clinical tests were negative. Author
APPROVED FOR PUBLIC RELEASE