REGULATION OF LIPID TRANSPORT AND DEPOSITION. ROLE OF THE SYMPATHETIC NERVOUS SYSTEM.
Rept. for 1 Oct 63-31 Oct 66,
MILAN UNIV (ITALY) INST OF PHARMACOLOGY
Pagination or Media Count:
Epinephrine and norepinephrine mobilize lipid and elevate serum free fatty acid FFA levels. These effects are mediated by the sympathetic nervous system interacting with the adrenal medulla. To clarify the role of the sympathetic nervous system, in rats of one group the peripheral ganglia of the sympathetic nervous system were destroyed by immunosympathectomy, and the response of these rats to the stress of cold was observed. Immunosympathectomized rats were able to survive exposure to cold almost as well as normal rats however, removal of the adrenal medullae to deprive the immunosympathectomized rats of catecholamines rendered such rats susceptible to cold exposure. These results clearly confirm the key role of catecholamines in metabolic reactions required to mobilize stores of body energy during exposure to cold. Author
- Anatomy and Physiology