REGULATION OF LIPID TRANSPORT AND DEPOSITION. EFFECT OF ESSENTIAL FATTY ACID DEFICIENCY.
Rept. for 1 Oct 63-31 Oct 66,
MILAN UNIV (ITALY) INST OF PHARMACOLOGY
Pagination or Media Count:
The incorporation of labeled glucose and palmitic acid into triglycerides was studied in vitro in adipose tissue from normal rats and rats deficient in essential fatty acids EFA. While incorporation of both precursors was greater in EFA-deficient tissues than in the normal, this difference did not reflect a qualitative shift in metabolism. The findings are compatible with the hypothesis that EFA deficiency results in deficiency in the biosynthesis of prostaglandins. This lack, in turn, may have caused greater lipolysis, which may have accelerated synthesis of triglyceride. Thus, both mobilization and deposition of lipid were apparently affected by prostaglandins and by a deficiency of EFA. Author
- Anatomy and Physiology