RADIATION DAMAGE IN MUSCLE MEMBRANES AND REGULATION OF CELL METABOLISM.
Final progress rept. no. 3, Feb 62-Apr 67,
BUENOS AIRES UNIV (ARGENTINA) FACULTAD DE CIENCIAS MEDICAS
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The study is concerned with the effect of x-radiation upon those properties and function of muscle cells. The research program was additionally extended to the study of cell membrane behaviour under the presence of cesium and quaternary ammonium ions, as well as to chemical damage studies with enzyme upon the molecular membrane structure. Unfortunately it was not possible to accomplish the proposed idea of studying the effects of x-radiation on the membrane mechanisms related to the Ach, Ch interaction, as well as the comparison of the radiation changes and the enzymatic alteration on the muscle membrane. The comparison between, mechanical, electrochemical, biochemical and structural changes in frog muscles following x-irradiation have contributed fundamentally to a basic understanding of the effects of irradiation on membrane system and control mechanism. Basically, the contribution was again oriented to obtain a better understanding of the effects of ionizing radiation in the sequence of processes taking place in the membrane and responsible for regulating the membrane potential as well as the membrane organization and function. Changes in the membrane permeability, and processes of membrane potential regulation, as well as in the processes related to uncoupling of oxidation and phosphorilation, due to radiation were considered an important observation of cell damage. Author
- Anatomy and Physiology