Performance and Biochemical Responses Related to Social Changes Versus Chemotherapy in Nonhuman Primates (Rhesus Monkeys)
Technical Report,01 Nov 1966,31 Jul 1967
FLORIDA PRESBYTERIAN COLL ST PETERSBURG ST PETERSBURG United States
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A study was made to determine the effects of social change versus chemotherapy upon performance and biochemical response in nonhuman primates rhesus monkeys. Twenty-four male rhesus monkeys from 26-30 months of age were used for this research. The results indicated the following 1 Performance of complex discrimination improves for social subdominant animals changed to isolation 2 performance of complex discrimination shows a decrement for isolated animals which become subdominant after the change to a state of social companionship 3 social status along the dominant-sub-dominant scale seems to be more important for prediction of performance than the perceptual conditions of the living environment 4 both changed environments and injections of Stelazine trifluoperazine improved the biochemical condition of subjects so treated 5 there was little or no difference between the relative therapeutic effects of changed social environments and Stelazine injections 6 Stelazine reduced sensitivity to shock in a shock-escape match-to-sample task according to degrees of previous environmental stimulation during early rearing. The least affected Ss were the animals reared in strict isolation. Both partial isolates and normal social Ss were moderately affected. The greatest reduction of reactivity was observed in the enriched social Ss. The noted effects were interpreted as indicating differential early sensory threshold development in the four rearing groups used in this experiment 7 differential rearing conditions, as used in this study, had no effect upon any of the factors mentioned above.