VALIDITY OF THE HUMAN 17-HYDROXYCORTICOSTEROID/CREATININE RATIO.
Final rept. Apr 66-May 67,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
Pagination or Media Count:
Short-term and long-term trends for urinary creatinine excretion rate, 17-hydroxycorticosteroid 17-OHCS excretion rate, and the 17-OHCScreatinine ratio were investigated, utilizing data obtained from 11 healthy men during forenoon and afternoon periods on 5 consecutive days in each of 4 consecutive weeks. Creatinine excretion rate did not show significant forenoon-afternoon variation, but there was forenoon-afternoon variation P .01 for both 17-OHCS excretion rate and the 17-OHCScreatinine ratio, each declining as time proceeded. Using creatinine as the base for 17-OHCS did not cause distortion instead, there was a statistical gain, as the variance was then lessened. Significant week-to-week variation was detected only in afternoon data, and it was limited to creatinine excretion rate P .001 and 17-OHCS excretion rate P .01, both declining progressively over the 4-week test period. Since the 17-OHCScreatinine ratio did not show week-to-week variation, it was concluded that creatinine acted as a correction factor, eliminating the long-term variation in 17-OHCS. Author
- Anatomy and Physiology