PROPERTIES OF ELECTRICALLY EXCITABLE MEMBRANES
Final rept. 1 Oct 1966-30 Sep 1967
WASHINGTON UNIV ST LOUIS MO DEPT OF ELECTRICAL ENGINEERING
Pagination or Media Count:
Although the broad outlines of the electrical excitation of membranes are now moderately well understood, the majority of the finer details remain to be worked out for example, the action potential is known to arise from a transient shift in the membranes ionic permeabilities, but the methods or even the rules by which a membrane distinguished ions, the properties of the distinguishing structures, and the nature of ion transit through the membrane are as yet incompletely explained. In the research proposed it is planned to approach the problem pharmacologically by challenging various excitable membranes with a variety of cations, anaesthetics, and toxins and observing their response by means of the voltage clamp technique. Ideally, this will lead to new empirical rules of membrane behavior and shed additional light on the basic processes which interact to generate the action potential.
- Anatomy and Physiology