Accession Number:

AD0661978

Title:

Growth of the Young Male Rat in a Hyperoxic Environment

Descriptive Note:

Technical Report,01 Sep 1966,01 Apr 1967

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX BROOKS AFB

Report Date:

1967-09-01

Pagination or Media Count:

29.0

Abstract:

Young male rats were maintained continuously in a hyperoxic environment for periods up to 8 weeks. During this time, the animals were subjected to an oxygen partial pressure of 369 mm. Hg 97.1 at a simulated altitude of 380 mm. Hg 18,000 ft. The parameters chosen to delineate growth and development in the rat were total body weight gain weight gain of the liver, kidney, testis, spleen, lung, adrenal, heart, and brain deoxyribonucleic acid DNA, ribonucleic acid RNA, and protein content of these organs incorporation of 14C-leucine into liver protein and serum lactate dehydrogenase LDH isozymes. In spite of the changes reported in the text, the animals grew well in this atmosphere however, it should be noted that several fundamental changes were observed in the growth and development on the cellular level.

Subject Categories:

  • Stress Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE