Ultratstructural Studies of X-ray Induced Glomerulosclerosis in Rats Subjected to Uninephrectomy and Food Restriction
NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO United States
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Weanling female Sprague-Dawley rats were utilized to study the effect of undernutrition on the ultrastructure of accelerated irradiation induced glomerulosclerosis. Following uninephrectomy and 2000 rad X-rays to the remaining kidney, a severe, destructive glomerulosclerosis appeared within 7-8 weeks. Food restriction to the point of significant growth retardation resulted in a marked inhibition of the genesis of the glomerular lesion. Ultrastructurally there was marked reduction in all cytoplasm organelles and a striking reduction in mesangial matrix deposition. These observations show that food restriction retards the development of manifestation of what is considered to be a direct radiation effect on the kidney and add further confirmation to the thesis that a stimulus for growth, combined with the direct effects of radiation accelerates the development of glomerulosclerosis, while growth retardation has a profound inhibiting effect on the evolution of the lesion.