STUDIES ON CHEMOTHERAPY AND SERODIAGNOSIS FOR CLONORCHIS SINENSIS INFECTION.
Final rept. no. 4, Jun 66-Jun 67,
CHIBA UNIV (JAPAN) DEPT OF PARASITOLOGY
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A previous paper reported that 6 66.6 out of 9 cases of clonorchiasis patients treated with 50 mgkg of 1,4-bis-trichloromethylbenzol for 5 consecutive days, 7 42.8 out of 14 with 40 mgkg and 2 15.8 out of 13 with 30 mgkg were considered to be completely cured. In the present trial, a second mass-treatment of clonorchiasis with 1,4-bis-trichloromethylbenzol was carried out. Ninety-nine patients were treated, dividing them into 3 groups according to the doses, 50 mgkg, 60 mgkg and 70 mgkg, for 5 consecutive days. Follow-up studies for one year after treatment showed complete cure in 21 67.7 out of 31 patients with 50 mgkg, in 23 83.1 of 28 with 60 mgkg and in 27 87.0 of 31 with 70 mgkg. Difference in size of dose produced no difference at all in the incidence and severity of the side effects. Subacute and chronic toxicity tests of the drug were carried out in rats. Adult rats were divided into groups and given 100 mgkg, 200 mgkg, 300 mgkg and 500 mgkg, respectively, daily by mouth for 4 weeks and another group was given 100 mgkg daily for 12 weeks. The administration to rats of 1,4-bis-trichloromethylbenzol in dose of 100 mgkg daily for 12 weeks produced no toxicity at all however, in the dose of 200 mgkg or more daily, the administration for even 4 weeks produced toxicity in rats. It is concluded from the result that there is practically no danger so long as its administration in the order of 100 mgkg or less daily for 5 days. Author
- Medicine and Medical Research