DRUGS AND EXPERIMENTAL CONDITIONS AFFECTEING LIPID TRANSPORT AND DEPOSITION.
Final scientific rept. 1 Nov 63-31 Oct 66,
MILAN UNIV (ITALY) INST OF PHARMACOLOGY
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The effect of drugs affecting lipid mobilization nicotinic acid and transport glucagon are investigated in vitro and in vivo. The interactions with the nervous and hormonal control of lipid transport and particularly with the sympathetic system and prostaglandins are investigated using experimental conditions of increased and decreased hormonal activity. Our experiments indicate the presence of mechanisms which modulate the metabolic effect of catecholamines in adipose tissue. It is of particular interest to observe that prostaglandins antagonize the lipolytic hormones in the fed, but not in the fasted animals and that, on the other hand, a dietary induced deficiency in essential fatty acids, the biosynthetic precursors of prostaglandins, elicits exagerated FFA release in response to the adrenergic stimulation of the lipolytic system. Author