Accession Number:

AD0659026

Title:

HOMOGRAFT RESPONSE IN ADULT-THYMECTOMIZED MICE: DEFICIENCY WITH AGING AND AFTER LOW DOSE-RATE GAMMA-IRRADIATION,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Report Date:

1967-08-04

Pagination or Media Count:

25.0

Abstract:

The homograft response to skin grafts of varying antigenic disparity was measured at 15-20 months of age in mice thymectomized at 8 weeks of age. The response to male isografts was delayed more in thymectomized female recipients than in intact recipients. Exposure of female mice to sublethal X radiation at 10-11 weeks of age resulted in a further delay in intact recipients and abrogated the response in the thymectomized recipients. Other intact but aged mice showed a slight impairment of response to skin grafts differing at non-H-2 loci. In thymectomized groups, this impairment was increased. Exposure of both intact or thymectomized mice at 9 months of age to 1133 rad of low dose rate gamma-radiation 1.4 radhr resulted in an increased delay in response relative to the nonirradiated groups. In all cases, the non-H-2 grafts were the most affected by radiation and thymectomy. It is concluded 1 After adult thymectomy, the homograft response becomes deficient in old mice, particularly as regards male or non-H-2 isoantigens. 2 Chronic gamma-irradiation after thymectomy further increases this deficiency, presumably by creating a greater demand for new immunocompetent cells andor by eliciting defects in their precursors. Author

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE