Accession Number:

AD0658972

Title:

IMMUNOGENIC RESPONSE OF THE VENOMS OF FER-DE-LANCE (BOTHROPS ATROX ASPER) AND LACASCABELLA (CROTALUS DURISSUS DURISSUS) FOLLOWING PHOTOOXIDATIVE DETOXIFICATION.

Descriptive Note:

Final rept.,

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1967-06-30

Pagination or Media Count:

18.0

Abstract:

Photooxidation of crude B. atrox asper and C. durissus durissus venom by visible light in the presence of methylene blue resulted in the detoxification of these venoms and a considerable reduction of some enzymatic activities. Immunization of rabbits with the photooxidized venoms and isolation of their gamma-globulins revealed that the immunoglobulins obtained with B. atrox asper venom did not protect mice from the effects of this venom while the gamma-globulins from C. durissus durissus animals gave a very high degree of protection. The possible cause of this discrepancy is discussed. Author

Subject Categories:

  • Anatomy and Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE