ENDOGENEOUS MECHANISM OF VASCULAR RESPONSE IN INFLAMMATION, WITH SPECIAL REFERENCE TO BIOLOGIC SIGNIFICANCE OF SPECIFIC PERMEABILITY FACTORS AND THEIR INHIBITORS NEWLY ISOLATED FROM INFLAMED SITES.
Final rept. 11 Jun 66-10 Jun 67,
KUMAMOTO UNIV (JAPAN) MEDICAL SCHOOL
Pagination or Media Count:
A permeability factor responsible for the delayed Arthus vascular response was previously discovered in the local skin site. The Arthus permeability factor was found to be a complex of three factors I, II and III. Successful purification by chromatography of factors II and III was performed these substances were non-diffusible and thermostable peptides, and behaved as homogeneous substances on electrophoresis and ultracentrifugation. A similar permeability factor was also discovered in the delayed thermal vascular lesion. The permeability factor was also made up of three factors, I, II and III. The factors II and III showing a stronger permeability-increasing effect were successfully purified by chromatography. The effect of all these factors was long-active on experimental injection in contrast to short-living effect of permeability factors which were reported from other laboratories. The observations would seem to be very important for the endogeneous mechanism of increased vascular permeability in inflammation.
- Anatomy and Physiology
- Medicine and Medical Research