Accession Number:

AD0658462

Title:

DECREASED ATROPINE TOXICITY IN RATS CHRONICALLY EXPOSED TO COLD,

Descriptive Note:

Corporate Author:

PITTSBURGH UNIV PA DEPT OF PHARMACOLOGY

Report Date:

1967-09-01

Pagination or Media Count:

25.0

Abstract:

Environmental conditioning to cold has been shown to be able to alter the toxicity of atropine sulfate to rats when administered by an i.p., but not by an i.v. route. Rats exposed to 5C for 49 days tolerate twice the amount of atropine sulfate tolerated by rats exposed to 5C for only 1 day. This tolerance appears to correlate with a slower absorption of the drug from the peritoneal cavity compared with the absorption rates for acutely cold-exposed rats, or rats maintained at 25C. Although excretion of drug into the urine and bile is not higher for the chronic cold animal, its tissue distribution is somewhat lower. This is consistent with the suggestion that the cold-acclimated rat decreases the toxicity of atropine by limiting absorption rather than by increasing excretion. Author

Subject Categories:

  • Stress Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE