SECONDARY EVALUATION OF POTENTIAL ANTIMALARIAL AGENTS.
Annual progress rept. 1 Aug 66-31 Jul 67,
IIT RESEARCH INST CHICAGO ILL
Pagination or Media Count:
The objectives of this program are to screen compounds against normal and drug-resistant strains of malaria and to develop procedures for use in low-temperature storage of plasmodia. Secondary screening of chemicals against normal P. berghei was continued. Test procedures were developed and utilized for screening against chloroquine-, triazine-, and DDS-resistant P. berghei in mice. A serum-free preservative was developed that maintained the viability and virulence of sensitive and drug-resistant malaria after storage at -196C for up to 225 days. This solution was also used to determine whether a splenic bank could be used as an alternative to an erythrocytic bank for the low-temperature storage of plasmodia. Author