Accession Number:

AD0658234

Title:

SECONDARY EVALUATION OF POTENTIAL ANTIMALARIAL AGENTS.

Descriptive Note:

Annual progress rept. 1 Aug 66-31 Jul 67,

Corporate Author:

IIT RESEARCH INST CHICAGO ILL

Personal Author(s):

Report Date:

1967-07-01

Pagination or Media Count:

55.0

Abstract:

The objectives of this program are to screen compounds against normal and drug-resistant strains of malaria and to develop procedures for use in low-temperature storage of plasmodia. Secondary screening of chemicals against normal P. berghei was continued. Test procedures were developed and utilized for screening against chloroquine-, triazine-, and DDS-resistant P. berghei in mice. A serum-free preservative was developed that maintained the viability and virulence of sensitive and drug-resistant malaria after storage at -196C for up to 225 days. This solution was also used to determine whether a splenic bank could be used as an alternative to an erythrocytic bank for the low-temperature storage of plasmodia. Author

Subject Categories:

  • Biology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE