Accession Number:

AD0657859

Title:

USE OF GERMFREE ANIMALS IN THE STUDY OF DENTAL CARIES.

Descriptive Note:

Final technical rept. 1 Aug 62-31 Jul 65,

Corporate Author:

CHICAGO UNIV ILL ZOLLER MEMORIAL DENTAL CLINIC

Report Date:

1967-09-07

Pagination or Media Count:

5.0

Abstract:

Over the years, it has been possible to demonstrate that in the complete absence of all bacteria, germfree rats could not develop dental decay even though ingesting a caries-inducing diet for as long as 150 days when the early experiments were terminated. Later, in the presence of an enterococcus Streptococcus sp isolated from a rat in the external environment and with dental caries, otherwise germfree rats developed caries, though a longer time period was involved. Both in one early group of rats, as well as in several later groups of otherwise germfree rats inoculated with a lactobacillus strain, originally isolated from a human mouth with caries, dental caries did occur in some rats molar teeth, but especially so in subsequent generations of rats living in such a lactobacillus environment. Inoculated leptotrichia-like filamentous bacteria were difficult to establish and failed to induce caries in otherwise germfree gnotobiotic rats. Finally, in recently-observed animals maintained their life span on caries-inducing diets, no dental decay could be detected, thus conclusively demonstrating the etiological relationship of bacteria and dental caries in this kind of unique study. Author

Subject Categories:

  • Animal Husbandry and Veterinary Medicine
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE