WATER INSOLUBLE DERIVATIVES OF PROTEINS WITH BIOLOGICAL ACTIVITY.
Final technical rept. 1 Jul 66-30 Jun 67,
WEIZMANN INST OF SCIENCE REHOVOTH (ISRAEL)
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A number of derivatives of papain and chymotypsin were prepared in which the active enzyme was covalently bound to a high-molecular weight carrier e.g., poly-L-ornithyl papain, poly-L-glutamyl chymotrypsin. A kinetic study was made of these compounds, with particular attention given to pH activity profiles. Papain-collodion membranes were also prepared and were examined with respect to the effect of local gradients of enzyme and substrate on their kinetic activity.