SYNTHESIS OF ATROPINE LABELED WITH C14 IN THE TROPINE RING AND EFFECT OF COLD ACCLIMATION ON ATROPINE METABOLISM
PITTSBURGH UNIV PA SCHOOL OF MEDICINE
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An investigation was directed to scaling down from 5 gm. to 300-400 mg level the synthesis of tropinone from succinic acid. Detailed studies for the formation of tropinone from precursor, conversion of tropinone to tropine and formation of atropine via the esterification of tropine with tropic acid was conducted. Work was also undertaken on the labeling of atropine. After several abortive attempts, a small yield of N-Me14 tropine was obtained. A batch of N- Me14-atropine has been prepared from the N-Me14-tropine this material was used for some metabolic studies in mice. Two attempts at making ring-labeled atropine are in progress. The 3-C14, and the 2,3,4-C14-atropine were prepared, but the yields and specific activities were lower than anticipated.
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