COMPUTER ASSISTED ELECTROENCEPHALOGRAPHIC ANALYSIS OF CHICK PYRIDOXINE DEFICIENCY STATES.
TEXAS UNIV AUSTIN LABS FOR ELECTRONICS AND RELATED SCIENCE RESEARCH
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The hypothesis that computer-assisted, electroencephalographic EEG monitoring of control and Vitamin B6 pyridoxine deficient chicks could provide an analytical basis for the detection of pyridoxine insufficiency in advance of the symptomatic stages of this deficiency syndrome was tested in this research. The symptomatic criteria employed were weight differences between groups and behavioral hyperirritability. Daily weight records were kept on all chicks. The deficient subjects were placed on 98 per cent pyridoxine deficient chick ration. Dietary manipulation of pyridoxine deficiency status was carried out as follows One group was pre-standardized on control ration and then transferred to deficient ration on day nine post-hatched. This group provided the basis for monitoring the EEG transition from optimal to insufficient pyridoxine nutrition, and was designated the Short Term Deficient STD group. Another group was placed on the same deficient ration on day one and provided the EEG correlates for the more chronic stages of this deficiency syndrome, and was designated the Long Term Deficient LTD group. On the seventh day symmetrical, gross, bipolar depth electrodes were implanted into the chicks cerebral lobe hyperstriatum. Post-operative healing was complete twenty-four hours later which permitted the initiation on day nine of daily EEG monitoring for the LTD and Control groups and monitoring every twelve hours for the STD group. The important electrographic finding was that of a significant, mean amplitude facilitation of short-latency for the STD chicks that occurred 24 hours after they had been transferred to the deficient ration. Author
- Medicine and Medical Research