STRUCTURAL STUDIES IN VIRAL HEPATITIS.
Progress rept. 1 Jul 66-31 Jul 67,
MOUNT SINAI HOSPITAL NEW YORK
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The investigations concerned, besides various consultation activity on projects on viral hepatitis, the conventional electron microscopic study of the hepatitis induced in marmosets by the demonstration of icterogenic serum. The hepatitis has some but not all hallmarks of human viral hepatitis. It differs particularly by the absence of cholestasis and lysosomal activation. However, so far unidentified bodies were noted in the cytoplasm, which are considerably smaller than ribosomes. Human viral hepatitis reveals fine structural changes related to reduced hepatic function, but no specific diagnostic criteria. Massive necrosis in viral hepatitis was closely investigated. Additional studies covering aspects of viral hepatitis included the pathogenesis of cholestasis, immunologic liver injury, morphologic characteristics for chronicity in liver injury and the manifestation of anabolic liver injury. Author
- Medicine and Medical Research