STUDIES RELATED TO AN EARLY DETECTION OF TOXIC EFFECTS OF ORGANIC CHEMICALS.
Final rept. Oct 65-31 Aug 67,
KANSAS UNIV LAWRENCE
Pagination or Media Count:
Inhalation of methylchloroform containing air in a continuous flow inhalation chamber altered the pharmacological responsiveness of the exposed animal. It decreased the duration of hypnosis induced by hexobarbital or pentobarbital but did not affect the barbital or chloralhydrate hypnosis. There was a significant increase in the hexobarbital oxidase activity of the liver microsomes but the microsomal nitro-reductase was not affected. The pharmacological as well as the biochemical changes were reversible. They were blocked by the pretreatment with ethionine. Intraperitoneal injections of methylchloroform produced effects which were opposite to those produced by its inhalation. The pentobarbital hypnosis was prolonged and the liver hexobarbital oxidase activity was depressed. It is concluded that methylchloroform produced specific changes in the drug metabolising enzyme systems. The nature of these changes were related to the route of administration of this agent. Author