Accession Number:

AD0656876

Title:

INTERSTITIAL PULMONARY EDEMA: AN ELECTRON MICROSCOPIC STUDY OF THE PATHOLOGY OF STAPHYLOCOCCAL ENTEROTOXEMIA IN RHESUS MONKEYS

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Personal Author(s):

• Finegold, Milton J.

Report Date:

1967-03-01

Pagination or Media Count:

14.0

Abstract:

Interstitial pulmonary edema was produced in rhesus monkeys by intravenous injections of staphylococcal enterotoxin B, a purified protein toxin. The primary pathologic change, as revealed by electron microscopy, was capillary endothelial cell degeneration and necrosis, with less frequent damage to the endothelium of venules. Secondary phenomena were interstitial hemorrhage and edema and a histiocytic infiltrate. There was striking herniation of capillary endothelium into the vascular lumen which may contribute significantly to decreased pulmonary perfusion in this toxemia.

Descriptors:

• *LUNG
• *STAPHYLOCOCCUS
• *EDEMA
• TOXICITY
• PATHOLOGY
• HEMORRHAGE
• MONKEYS
• TOXINS AND ANTITOXINS
• ELECTRON MICROSCOPY

Subject Categories:

• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE