INTERSTITIAL PULMONARY EDEMA: AN ELECTRON MICROSCOPIC STUDY OF THE PATHOLOGY OF STAPHYLOCOCCAL ENTEROTOXEMIA IN RHESUS MONKEYS
FORT DETRICK FREDERICK MD
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Interstitial pulmonary edema was produced in rhesus monkeys by intravenous injections of staphylococcal enterotoxin B, a purified protein toxin. The primary pathologic change, as revealed by electron microscopy, was capillary endothelial cell degeneration and necrosis, with less frequent damage to the endothelium of venules. Secondary phenomena were interstitial hemorrhage and edema and a histiocytic infiltrate. There was striking herniation of capillary endothelium into the vascular lumen which may contribute significantly to decreased pulmonary perfusion in this toxemia.