Accession Number:

AD0656690

Title:

FIXED AND REPRODUCIBLE ORTHOSTATIC PROTEINURIA.

Descriptive Note:

Final rept. (Phase I) Jan 64-Dec 66,

Corporate Author:

WILFORD HALL HOSPITAL (AIR FORCE) LACKLAND AFB TEX

Personal Author(s):

• Lecocq,Frank R.
• McPhaul,John J.
• Phillippi,Paul J.
• Robinson,Roscoe R.

Report Date:

1967-06-01

Pagination or Media Count:

18.0

Abstract:

Recent observations in patients with fixed and reproducible orthostatic proteinuria suggest that earlier concepts regarding its etiology and prognosis may be incorrect. Patients with orthostatic proteinuria exhibit a renal hemodynamic response to standing which resembles that observed in normal subjects. The demonstration of histologic alterations of the glomeruli in a high percentage of renal biopsy specimens from young patients with fixed orthostatic proteinuria has provided a reasonable primary explanation for this type of proteinuria. Other investigations suggest that the usual upright reduction of renal blood flow may permit an increased trans-glomerular transfer of protein across the altered capillary wall. Follow-up observations on large numbers of young men with this condition at Wilford Hall USAF Hospital have shown that fixed and reproducible orthostatic proteinuria is not always a transitory condition of adolescence and that it may reflect the existence of underlying mild renal parenchymal disease whose final clinical expression is still unknown. Subsequent five-year follow-up evaluation of these patients will clarify the current uncertainty regarding the long-term prognosis for patients with this disorder. Author

Descriptors:

• *PROTEINS
• *KIDNEYS
• EXCRETION
• DISEASES
• ETIOLOGY
• HISTOLOGY
• BIOPSY
• URINE
• TRANSPORT PROPERTIES
• CAPILLARIES(ANATOMY)
• DIAGNOSIS(MEDICINE)
• PATHOLOGY

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE