FIXED AND REPRODUCIBLE ORTHOSTATIC PROTEINURIA.
Final rept. (Phase I) Jan 64-Dec 66,
WILFORD HALL HOSPITAL (AIR FORCE) LACKLAND AFB TEX
Pagination or Media Count:
Recent observations in patients with fixed and reproducible orthostatic proteinuria suggest that earlier concepts regarding its etiology and prognosis may be incorrect. Patients with orthostatic proteinuria exhibit a renal hemodynamic response to standing which resembles that observed in normal subjects. The demonstration of histologic alterations of the glomeruli in a high percentage of renal biopsy specimens from young patients with fixed orthostatic proteinuria has provided a reasonable primary explanation for this type of proteinuria. Other investigations suggest that the usual upright reduction of renal blood flow may permit an increased trans-glomerular transfer of protein across the altered capillary wall. Follow-up observations on large numbers of young men with this condition at Wilford Hall USAF Hospital have shown that fixed and reproducible orthostatic proteinuria is not always a transitory condition of adolescence and that it may reflect the existence of underlying mild renal parenchymal disease whose final clinical expression is still unknown. Subsequent five-year follow-up evaluation of these patients will clarify the current uncertainty regarding the long-term prognosis for patients with this disorder. Author
- Medicine and Medical Research