Accession Number:

AD0656687

Title:

FEEDING THROUGH THE SKIN WITH DIMETHYL SULFOXIDE.

Descriptive Note:

Final rept. Jun-Oct 65,

Corporate Author:

DARTMOUTH COLL HANOVER N H WILDER LAB

Personal Author(s):

• Smith,Robert E.
• Hegre,Andrew M. , Jr.
• Rieffel,Clement N. , Jr

Report Date:

1967-06-01

Pagination or Media Count:

12.0

Abstract:

The use of dimethyl sulfoxide DMSO to allow substances, including drugs, to pass through the skin had been reported in the literature. However, none of the studies pertained to the efficacy of using DMSO with nutrients. A seven-year-old Negro male dying of malnutrition, secondary to small bowel removal, was given several supplemental nutrients across the skin by the use of DMSO. A rise in blood glucose, serum carotene, urinary amino acids, and urinary Cobalt57B12, as well as a gain in weight after application of the nutrients to the skin, documented passage across the skin. The patient received 3,000 ml of 100 per cent DMSO during a seven-week period without evidence of toxicity. Author

Descriptors:

• *METABOLIC DISEASES
• CHEMOTHERAPY
• SULFOXIDES
• SKIN(ANATOMY)
• PERMEABILITY
• NUTRITION
• TOXICITY

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE