EFFECT OF HIGH ALTITUDE TO HEMATOPOIETIC PROCESS.
Final rept. no. 2, 1 Mar 66-28 Feb 67,
TOHO UNIV TOKYO (JAPAN) SCHOOL OF MEDICINE
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Changes in stroke volume of the right and left heart were studied in relation to tolerance to altitude. It was concluded that the pulmonary circulation might be regarded as a limiting factor of importance for performance at altitude. Chronic experiments on rabbits with chronic implanted heart electrodes were performed with partial success. The animals can be kept alive about one month after the operation. The results of these chronic experiments showed that the contractile capacity of the right heart is strengthened, increasing the right heart stroke volume within one week period of training-exposure to hypoxic condition. This fact supports the view that the improvement of the right heart capacity might be involved in the establishment of acclimatization to altitude. Changes in ascorbic acid in different organs at altitude are being studied in order to elucidate the role of this substance in acclimatization or tolerance to altitude. The results obtained so far show that the well acclimatized or tolerant animals have a larger capacity for utilizing ascorbic acid at altitude than do unacclimatized or less tolerant animals. This suggests that the administration of large amount of ascorbic acid may improve the tolerance to hypoxia. Author
- Anatomy and Physiology
- Stress Physiology