STUDIES OF LIFE SPAN DIETARY SODIUM CHLORIDE TOXICITY IN ANIMALS.
Annual progress rept. 1 Aug 66-15 Jul 67,
VANDERBILT UNIV NASHVILLE TENN SCHOOL OF MEDICINE
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The objective of the research was to determine whether consistent, significant differences in response to life span dietary sodium chloride levels occur in dogs, and, if so, the influence of sex and genetics and exploration of the significance in the occurance of arterial hypertension and atheroschlerosis in man. Twenty-five beagles 10 males and 15 females from unrelated AKC registered litters, whelped May 1965 had carotid loop procedures October 1965, baseline physiologic measurements until Feb. 1966, when 1 male and 1 female from each litter were randomly assigned to rations containing 1.5, 6 and 12 NaCl. Daily maintenance and primary care, monthly veterinary inspection, blood pressure measurements, weighing, quarterly urine and blood collections and bi-annual ECGs are done at a farm in a converted dairy barn. Gross and microscopic pathology, serology, and urinalysis are done in medical school laboratories. Weights remained relatively constant. Mean arterial blood pressures continued close to baseline with occassional pressures of 130 mmHG or more not notable between litters, sexes, or NaCl in rations. No abnormalities in urinalysis, blood components and metabolic constituents or electrocardiograms were observed. The slight elevations in serum cholesterol are probably attributable to change from puppy to adult. Author
- Medicine and Medical Research