INVESTIGATION OF THE EFFECTS OF ACTIVITY AND ENVIRONMENT ON ATABRINE THERAPY.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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The purposes of the research were 1 To determine with each of two recommended suppressive regimens administered to troops during active training a the time required to develop equilibrium plasma atabrine levels b the magnitude of the level in relation to dosage and c the variability in levels among individuals on the same regimen. 2 To determine the effect of high initial doses in shortening the time required to reach equilibrium levels. 3 To determine the effects of a simulated jungle climate upon the plasma atabrine levels. 4 To study the rate of reduction of plasma atabrine levels after discontinuing administration of the drug. 5 To study the relationship between the plasma atabrine levels obtained with therapeutic doses and those established previously with suppressive regimens. Author