ECOLOGY OF DENGUE AND OTHER ARBOVIRUSES OF MALAYSIA
Progress rept. 1 May 1966-1 May 1967
CALIFORNIA UNIV SAN FRANCISCO GEORGE WILLIAMS HOOPER FOUNDATION
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The program objectives are to determine the roles that arboviruses play in producing infection andor disease in man, with special reference to their ecology and the clarification of the non-urban cycles of dengue. The survey investigated a great variety of areas of differing ecology throughout Malaysia. Improved and intensified methods of collection allowed sampling of great numbers of mosquitoes for virus isolation. Predominant species, species composition and habits of mosquitoes in various areas were elucidated. Extensive collection of animals and human sera provided information on the incidence and distribution of arbovirus infection in man and animals, while the diagnostic service provided routine surveillance of arbovirus disease. Additional serological evidence strongly supporting a jungle cycle for dengue was obtained in wild monkeys and forest-dwelling aborigines, while no evidence was found to demonstrate significant involvement of any other animals. Bats showed evidence of group B infection, but this is probably not due to dengue virus. The discovery of Zika virus, previously known in Africa only, in Aedes aegypti and serological evidence of Zika infection in man and wild monkeys is significant. A new arbovirus, Seletar, is described and a large number of unidentified virus isolates from mosquitoes, ticks, and sentinel animals are being investigated. A serological survey of residents of Djakarta, Indonesia, the first to be done, revealed the occurrence of dengue and Japanese encephalitis and possibly chikungunya infection.
- Medicine and Medical Research