EFFECT OF TEMPERATURE AND DRUG THERAPY ON ANTHRAX INTOXICATION
FORT DETRICK FREDERICK MD
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In contrast to other known bacterial toxins and venoms, challenge with anthrax toxin resulted in a hypothermia which is as great as 14-15C in animals stressed by holdings at 4C. In comparison with animals held at room temperature following challenge, mean time to death is shortened in those animals held at 37C and extended at 4C became more susceptible to anthrax toxin, being killed by 8 rat units of toxin, whereas 16 units were required to kill animals held at room temperature. Antiserum, if administered through 60 minutes, prevented death of rats challenged with 15 units of toxin and tended to extend time to death of rats challenged with higher dosages of toxin. For animals challenged with 30 units of toxin and held at 24C, the drugs, caffeine, N-allyl-morphine, ACTH, hydrocortisone and barbituate were ineffective except for barbituate which extended time to death. All drugs were ineffective for rats stressed at 4C.