VASCULAR AND LYMPHATIC ABSORPTION OF RADIOACTIVE ALBUMIN FROM THE LUNGS
Technical Report,01 Jul 1965,01 Jul 1966
OXFORD UNIV (UNITED KINGDOM) OXFORD
Pagination or Media Count:
A study was made of the absorption of radioactive iodinated serum albumin RISA into the plasma after its instillation into the lungs of normal dogs and dogs with pulmonary edema in an effort to develop an indirect method for measuring lung lymph flow. Absorption of protein from the lung alveoli was intially slower in dogs with pulmonary edema compared with normal dogs however, by 24 hours, the percentage of the instilled dose of RISA present in the plasma was higher in the dogs with pulmonary edema than in the normal dogs. Absorption of RISA occurred equally well from the lung into the plasma whether or not the pulmonary artery to the lung was occluded, thus indicating that protein absorption could take place by means of the bronchial circulation. Bronchopneumonia was associated with a greatly accelerated entry of RISA from the lung into the plasma, showing a large increase in alveolar and capillary permeability in pneumonia. Measurements of changes in plasma concentration of RISA after its instillation into the lung cannot be used to assess the rate of lymph formation in the lung since most of the protein is absorbed directly into the plasma both in normal animals and in those with pulmonary edema.
- Anatomy and Physiology
- Medicine and Medical Research