PECULIARITIES OF REGENERATION PROCESSES IN BONE TISSUE OF IRRADIATED ANIMALS.
NAVAL MEDICAL SCHOOL BETHESDA MD TRANSLATION SERVICE
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The normal processes of regeneration of bone tissue are characterized by sudden rise in metabolic reaction on the 6th-21st day after fracture. During this period there takes place intensive storing accumulation of glycogen, heightened activity of ferments on bone tissue, intensified mineral and protein components metabolism. General ionizing effect markedly distorts all normal processes of regeneration. Accumulation of mineral substances at the site of the fracture occurs later and is phasic in character. In the animals which had been radiated, this process occurs as though in two different phases and is much prolonged in time. The intensity of metabolism, after total radiation does not attain the same level as in the normal animals. Crystallization of bone callus is delayed the size of the crystals after radiation is twice smaller than normal. The development of osteoblastic tissue and the formation of bone rods in the callus is delayed. In the bone callus cartilage tissue and coarsely fibrous structures of the newly formed bone tissue are preserved. Under the effect of sublethal doses of total ionizing radiation some profound disturbances in metabolism occur in the animal organism and the processes of bone tissue regeneration assume some new qualitative peculiarities.
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