AVERSIVENESS OF GLUCAGON INJECTION TO HUNGRY RATS.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Glucagon mimics the aftereffects of carbohydrate intake by releasing glucose, stored in the liver, into the blood stream. Because injection of thiamine into thiamine deficient rats after they consume saccharin solution increases their subsequent intake of saccharin, it was conjectured that glucagon would have a corresponding effect on hungry rats. It was found, however, that contrary to expectation injection of 75 mcg of glucagon shortly after saccharin consumption depressed subsequent saccharin intake. Lower doses had no effect. Collateral work, substituting decaffeinated coffee for saccharin, did not reveal any rewarding effects of doses below the aversive level. Since 75 mcg of glucagon inhibits the stomach contractions of hungry rats, the prevalent notion that this inhibition is similar to satiety seems incorrect, since satiety would presumably be rewarding. Author
- Anatomy and Physiology