COMPARISON STUDIES OF WHOLE BLOOD STORED IN ACD AND CPD AND WITH ADENINE.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
Pagination or Media Count:
Using 70 post-transfusion survival as the criteria, ACD and CPD anticoagulant solutions with and without adenine were tested after storage for 28, 35 or 42 days. At 28 days, all solutions had average survivals of 70 or better. The ACD and CPD solutions were below this at 35 and 42 days. However, the solutions with adenine had values over 70 for 35 and 42 days. There was no statistical difference between the basic anticoagulant solutions with or without adenine. In comparing two units obtained from the same subject, survival percentages were significantly higher in almost every unit when adenine was present. Other chemical determinations did not show harmful changes and no toxic effects were observed in the recipients. Since all units containing adenine had survival values greater than 70 in the 28- and 35-day periods, these units would appear to have been effectively preserved and blood stored under these conditions could be used in routine transfusions, reserving units stored 42 days for emergency use. Author