EFFECT OF INTRARECTAL DEXAMETHASONE ON SERUM FREE 17-OHCS LEVELS.
Rept. for 15 May-15 Jun 66,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
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The small-volume, water-soluble corticosteroid enema is valuable in treating ulcerative proctitis and mild ulcerative colitis. Approximately one-third of the dose is absorbed into the systemic circulation, an amount sufficient to produce pituitary-adrenal suppression. Dexamethasone 1 mg. orally or dexamethasone-21-phosphate 2 mg. administered in 45 ml. of warm tap water as a retention enema to healthy volunteers at 800 a.m. produced highly significant depression of the 300 p.m. serum 17-hydroxy-corticosteroids compared to controls P .01. Interpolation of these acute results to the long-term administration of soluble corticosteroid enemas would suggest that chronic pituitary-adrenal suppression may occur after discontinuation of therapy. Author
- Medicine and Medical Research