Accession Number:

AD0653941

Title:

EFFECT OF INTRARECTAL DEXAMETHASONE ON SERUM FREE 17-OHCS LEVELS.

Descriptive Note:

Rept. for 15 May-15 Jun 66,

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

• Sparberg,Marshall
• Jenson,Robert L.
• Beering,Steven C.
• Shannon,Ira L.

Report Date:

1967-04-01

Pagination or Media Count:

9.0

Abstract:

The small-volume, water-soluble corticosteroid enema is valuable in treating ulcerative proctitis and mild ulcerative colitis. Approximately one-third of the dose is absorbed into the systemic circulation, an amount sufficient to produce pituitary-adrenal suppression. Dexamethasone 1 mg. orally or dexamethasone-21-phosphate 2 mg. administered in 45 ml. of warm tap water as a retention enema to healthy volunteers at 800 a.m. produced highly significant depression of the 300 p.m. serum 17-hydroxy-corticosteroids compared to controls P .01. Interpolation of these acute results to the long-term administration of soluble corticosteroid enemas would suggest that chronic pituitary-adrenal suppression may occur after discontinuation of therapy. Author

Descriptors:

• (*CORTICOSTEROID AGENTS
• CHEMOTHERAPY)
• PITUITARY GLAND
• ADRENAL GLANDS
• INHIBITION
• DOSAGE
• DIURNAL VARIATIONS
• PHARMACOLOGY
• ADRENOCORTICOTROPIC HORMONE

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE