Accession Number:

AD0653844

Title:

PRESERVATION OF RED CELLS IN THE FROZEN STATE WITH SUGARS AND MACROMOLECULAR ADDITIVES: MECHANISM OF INJURY OF FREEZING.

Descriptive Note:

Progress rept. no. 62,

Corporate Author:

JOHN S SHARPE RESEARCH FOUNDATION BRYN MAWR PA

Personal Author(s):

• Strumia,Max M.

Report Date:

1967-06-01

Pagination or Media Count:

31.0

Abstract:

The storage of ACD blood can be extended to eight weeks if the blood is incubated with adenine-inosine at the end of the storage period, when measure of viability is based on the accepted standard of an average survival of 70 or better of radioactivity of Cr51 tagged erythrocytes 24 hours posttransfusion. Evidence is presented suggesting that the absolute increase in ATP following incubation with adenine-inosine may not per se be solely responsible for the increased viability of erthrocytes. Author

Descriptors:

• (*ERYTHROCYTES
• PRESERVATION)
• ANTICOAGULANTS
• FREEZING
• VIABILITY
• STORAGE
• ADENINE
• TRACER STUDIES
• BLOOD TRANSFUSION
• ADENOSINE PHOSPHATES
• NUCLEOSIDES

Subject Categories:

• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE