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QUANTITATIVE STUDIES OF THE MICROCIRCULATION IN SHOCK.
Progress rept., 1 Jul 66-15 Feb 67,
CALIFORNIA UNIV SAN DIEGO LA JOLLA DEPT OF THE AEROSPACE AND MECHANICAL ENGINEERING SCIENCES
Pagination or Media Count:
Studies on hemorrhagic shock in the rat and rabbit were directed towards establishment of quantitative indicies of transport and exchange efficiency at the level of the blood capillaries. An updated version of the Landis micro-occlusion technique was used to calculate the rate of fluid movement across single capillaries in the mesentery and thereby filtration constants for arterioles, capillaries and venules. Micro-pressure transducers were designed to measure the distribution of capillary pressures throughout the microcirculatory apparatus and to record arteri 1-venous pressure differentials relative to flow rates recorded by motion pictures. The colloid osmotic pressure of blood plasma samples taken during the progression of the shock syndrome was measured by a newly adapted high speed osmometer. The above parameters should make it possible to separate the contribution of the physiological state of the vessel barrier from those of alterations in the physical properties of the blood per se in the light of the impairment of tissue nutrition which develops in severe shock. Furthermore, quantitative data of this kind will permit careful evaluation of therapeutic procedures and plasma expanders on the progression of the circulatory insufficiency. Author
APPROVED FOR PUBLIC RELEASE