Accession Number:

AD0653526

Title:

PATHOLOGY OF OXYGEN TOXICITY IN FORTY MACACA MULATTA

Descriptive Note:

Final rept, May 1965-Apr 1966

Corporate Author:

AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH

Personal Author(s):

• Robinson, Farrel R.
• Harper, David T.
• Kaplan, Harold P.
• Thomas, Anthony A.

Report Date:

1967-03-01

Pagination or Media Count:

23.0

Abstract:

Forty monkeys Macaca mulatta were exposed to 99-100 oxygen at pressures from 600 to 760 mm Hg. The acute exudative pulmonary response was seen in only three exposed at 760 mm Hg. The subacute proliferative pulmonary response was seen at all levels studied, the degree being directly related to time-dose exposures. In the high dose ranges clinical signs of illness were evident after 5-7 days exposure when the monkeys became listless and anoretic. By 14 days they were quite lethargic and had assumed a huddled position. Grossly, the heavy lungs had a gray, bloodless appearance. Microscopically, there was extreme proliferation of the interstitium and alveolar epithelium. None of the monkeys that were exposed at 600 mm Hg died, although mild focal proliferative changes were seen. After 31 days postexposure, these changes appeared as focal areas of atelectasis with mild septal fibrosis.

Descriptors:

• *OXYGEN
• *LUNG
• RECOVERY
• PATHOLOGY
• MORTALITY RATE
• MONKEYS
• PRESSURE BREATHING
• BIOPSY
• RESPONSE(BIOLOGY)
• RESPIRATORY SYSTEM
• TOXICITY

Subject Categories:

• Medicine and Medical Research
• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE